Neurobehavioral analysis of developmental iron deficiency in rats. Growth-promoting effects of iron- and cobalt- protoporphyrins on cultured embryonic cells. Exposure of rats to Pb during gestation Yang et al. The Bakersman Aug 20, In toto , our data indicate that gestational and lactational exposure to Mn and Pb alters iron metabolism and behavior in offspring in different ways. 
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No overt toxicity due to Mn or Pb exposures during gestation was observed in the dams. The effects of gestational and lactational Mn or Pb exposure on iron metabolism were examined by determining the kinetics of 59 Fe absorption from the gut, the disposition of absorbed 59 Fe, as well as the tissue distribution of 59 Fe at 4 and 24 hours after administration.
We sought to determine if iron absorption in the gut, blood clearance and tissue distribution are affected in metal-exposed pups. Pb exposure did not change 59 Fe braib from the gut nor DMT1 expression. Pathumwan, Bangkok Thailand.
At the end of the experiment, duodenal scrapings were collected from each pup for Or analyses. Since Mn or Pb may disrupt Fe metabolism by molecular mimicry, we examined the influence of gestational and lactational exposures on iron status.
Manganese II chloride tetrahydrate molecular bhold Biol Trace Elem Res. Blood and brain metal concentrations of pups within each exposure group were analyzed.
Mn uptake into the brain has been shown to be increased by iron deficiency Aschner and Aschner,Thompson et al. In contrast, only the plasma level was significantly higher in Pb-exposed pups after 59 Fe IV injection. For exposure studies, Mn 4.
However, the weight gain of pups from both Mn- and Pb-exposed dams was significantly lower from birth until the end of the experiments Figure 1. Compared to control values, tissue concentrations of IV-injected 59 Fe in the Mn-exposed pups were generally lower than control bone marrow, skeletal muscle and spleen.
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The precise pathways of Pb and Mn transport via the placenta or the uptake and secretion from the mammary glands into the milk are unknown. ZPP is a product of iron-deficient erythropoiesis, and is a normal metabolite formed from heme biosynthesis.
Lead exposure and the cognitive development of urban preschool children: Developmental lead exposure in rats: Blood samples were sequentially obtained from hrain tail vein over a hour period 5, 13, 30, 60, 90,m.
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Author information Copyright and License information Disclaimer. Metal inhibition of ferrochelatase. Intestinal DMT1 expression was elevated in Mn-exposed pups but the gut absorption of Fe was not significantly altered. More significant effects on body weights were observed in pups of both metal-exposed groups.
Regression analysis showed a significant correlation of brain to blood Mn concentration.
Plasma levels of 59 Fe over 24 h period post-intravenous A and post-gavage B dosing of pups. Figure 4A — Control closed squaresMn-exposed closed trianglesPb-exposed closed circles. What the hell is that? Brin distribution of manganese in the rat following inhalation exposure to manganese sulfate.
Pregnant dams were given distilled water, 4.
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Several factors may contribute to these discrepancies, such as exposure parameters and age of testing, as well as differences in the testing apparatus used. Feb 17, 2, 0 31 www. A significant correlation was found between blood and brain Mn but not for Pb. Manganese transport in eukaryotes: That beat scztter doooope.
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